Basic Information: What is Krystexxa Pegloticase

Krystexxa Pegloticase is a prescription medicine for adults who have tried other gout medicines and still have high uric acid and gout symptoms. It is a Pegylated uric acid specific enzyme indicated for the treatment of chronic gout in adult patients refractory to conventional therapy. To know more about this product, continue reading the complete review.


The most active ingredient of this product is pegloticase.

Other ingredients:

  • Disodium hydrogen phosphate dihydrate
  • Sodium chloride
  • Sodium dihydrogen phosphate dihydrate
  • Water for injection


For adult patients 8 mg can be given as an intravenous infusion every two weeks. It should not be administered as an intravenous push or bolus. It is advised to discontinue oral urate-lowering agents before starting this medication. It is important to monitor serum uric acid levels before each infusion. Also patients should be pre-medicated with antihistamines and corticosteroids. The Krystexxa admixture should only be administered by intravenous infusion over no less than 120 minutes via gravity feed, syringe-type pump, or infusion pump. The dosage form and strength is 1 ml sterile concentrate for dilution containing 8 mg of pegloticase protein, expressed in uricase protein amounts. It is not recommended for the treatment of asymptomatic hyperuricemia. Patients who have a genetic condition known as G6PD deficiency should not use this product.


The price of this product was unavailable in the manufacturer’s website, at the time of writing this review.

Possible Side Effects

Serious allergic reactions may happen in some people who receive Krystexxa. These allergic reactions can be life threatening and usually happen within two hours of the infusion. However, delayed-type hypersensitivity reactions have also been reported. Ideally, this product must be given by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with Krystexxa.  The most common side effects were gout flare-ups or attacks, infusion reactions, nausea, bruising, sore throat, constipation, chest pain, severe allergic reactions, and vomiting. An increase in gout flares is frequently observed in patients when they start taking Krystexxa to lower their uric acid levels. Patients do not need to stop taking Krystexxa simply because of gout flares. It is good to check with a medical professional for other medicines to help reduce your gout flares for the first few months after starting Krystexxa. Your doctor may stop Krystexxa if your uric acid levels do not become normal and stay controlled or you have certain side effects. It is not known if this product is safe and effective in children and should be kept away from the reach of children.

Manufacturer’s Commitment

There is no money back guarantee or return/refund policy advertised by the manufacturer advertised at the time of writing this review.

The Bottom Line

Based on the manufacturer’s claims this product is effective in lowering uric acid levels in the blood and reduce gout symptoms. Nevertheless, potential buyers may have some inhibitions in buying this product because of the possible adverse effects such as gout flares, infusion reactions, nausea, contusion or ecchymosis, nasopharyngitis,  constipation, chest pain, anaphylaxis, vomiting and congestive heart failure. Lack of a money back guarantee and lack of user reviews is another downside to this product. All in all, it looks like a prescription medication and not a natural supplement  that is safe from side effects.

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